Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting).

The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) The disease may be caused by mutations affecting the gene represented in this entry. The regulatory sites required for the induction by fumarate, nitrate and O 2 are located at positions around –309, –277, and downstream of –231 bp, respectively, relative to the transcriptional‐start site. The ND5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

It should be noted that while, in theory, two different sequences could RNAct, Protein-RNA interaction predictions for model organisms. We have already reported the neuroprotective effect of crude extract of A. africana NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 is a protein that in humans is encoded by the NDUFA1 gene. Please consider upgrading, NADH-ubiquinone oxidoreductase ESSS subunit. MT-ND5 and the rest of the mitochondrially encoded subunits are the most hydrophobic of the subunits of Complex I and form the core of the transmembrane region. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

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This section provides information on the location and the topology of the mature protein in the cell.

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Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.

The version number for both the entry and the canonical sequence are also displayed.

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This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

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This section contains any relevant information that doesn't fit in any other defined sections

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, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex I, Linear skin defects with multiple congenital anomalies 3 (LSDMCA3), Mitochondrial complex I deficiency, nuclear type 30 (MC1DN30), Am. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the IntAct database. The MT-ND4 gene provides instructions for making a protein called NADH dehydrogenase 4.

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. Complex I is composed of 45 different subunits (PubMed:12611891, PubMed:27626371). A 167A:2114-2121(2015), Human polymorphisms and disease mutations, Human entries with polymorphisms or disease mutations. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.

More information in the GO evidence code guide

,

UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF, Ghosh SS, Capaldi RA: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

Manually curated information for which there is published experimental evidence.

NADH-derived electrons can enter its mitochondrial respiratory chain either via a proton-translocating complex I NADH-dehydrogenase or via three putative alternative NADH dehydrogenases. MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS -

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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Sequence processingi: The displayed sequence is further processed into a mature form. [8][9] MT-ND5 is one of seven mitochondrial genes encoding subunits of the enzyme NADH dehydrogenase (ubiquinone), together with MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, and MT-ND6. Papers overview. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium. is extremely low.

These cellular structures produce energy through a process called oxidative phosphorylation, which uses oxygen and … [11] Those with MT-ND5 mutations can display the major features of MELAS and MERRF in some patients, as well as symptoms of Leigh's syndrome and/or Leber's hereditary optic neuropathy (LHON) in others. Sequence conflicts are usually of unknown origin.

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. The NADH dehydrogenase activities of membranes (0.4 to 0.5 μmol min −1 mg −1) did not differ significantly in the mutant and the wild-type strains, suggesting that the lack of a functional Na +-NQR complex in the mutant was compensated for by a nonelectrogenic NADH dehydrogenase encoded on the genome of V. cholerae. The disease is caused by mutations affecting the gene represented in this entry. The interaction with BCAP31 mediates mitochondria localization. The chemical reaction these enzymes catalyze are generally represented with the follow equation; It also includes information pertinent to the sequence(s), including length and molecular weight. The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH2). It is updated at every UniProt release.

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This section provides information on the tertiary and secondary structure of a protein.

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This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.

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This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.

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This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. All positional information in this entry refers to it.

This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s).

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Mitochondria are structures within cells that convert the energy from food into a form that cells can use. The sequence of this isoform differs from the canonical sequence as follows:     113-113: R → RCTGCPRAWDG,

Manually curated information that is based on statements in scientific articles for which there is no experimental support.

By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.

Examples: P92958, Q8TDN4, O14734

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This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.

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This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).

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This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Pyruvate dehydrogenase may be allosterically activated by fructose-1,6-bisphosphate and is inhibited by NADH and acetyl-CoA. Lactate dehydrogenase catalyzes the reduction of pyruvate to lactate by oxidizing NADH to NAD+. However, genes encoding subunits of the NADH dehydrogenase part of complex I are apparently missing in these species, so the complex might lack the NADH processing subunits. from the sequence. [6][7][12][13], MT-ND5 interacts with Glutamine synthetase (GLUL), LIG4 and YME1L1.[4]. [5], A small percentage of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) are caused by a G>A mutation at base pair 13513 in the MT-ND5 gene. Cardiac and renal involvement as well as symptoms such as myopathy and lactic acidosis can also be observed. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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This section provides any useful information about the protein, mostly biological knowledge.

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. (Adapted from PMID:21822288). Antiaris africanais a plant in Nigeria, generally used for the treatment of nervous disorders. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication GO - Molecular function i Manual assertion based on experiment ini, BioCyc Collection of Pathway/Genome Databases, Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, Eukaryotic Pathogen and Host Database Resources, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform,

Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.

The information is filed in different subsections. It is speculated that the chloroplast enzyme might use the quinone reductase function of the complex with a different reductant,- perhaps ferredoxin or NADPH. Both insertions were mapped to min 51, and sequence analysis revealed that both mutated genes encode proteins homologous to subunits of mitochondrial NADH dehydrogenase I. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:

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This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.

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This section describes post-translational modifications (PTMs) and/or processing events.

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This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.

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This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.

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, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial,

This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.

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This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. This respiratory entry point affects the amount of ATP produced per NADH/O 2 consumed and therefore impacts the maximum yield of biomass and/or cellular products from a given amount of substrate. We'd like to inform you that we have updated our Privacy Notice to comply The structure is L-shaped with a long, hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm that includes all the known redox centres and the NADH binding site. [10] Initially, NADH binds to Complex I and transfers two electrons to the isoalloxazine ring of the flavin mononucleotide (FMN) prosthetic arm to form FMNH2. Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. From: Mitochondrial Case Studies, 2016. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Nadh dehydrogenase (ubiquinone) activity Specific Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.

Inferred from Direct Assay

In metabolism: The nature of the respiratory chain …by an enzyme known as NADH dehydrogenase; the enzyme has as its coenzyme FMN. Semantic Scholar uses AI to extract papers important to this topic.

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.

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The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:

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Inferred from Mutant Phenotype

of multiple genes (paralogs).

Crystallographic studies indicate a homodimer structure, where the C-termini form an amphiphilic membrane-anchor domain and are necessary for FAD binding. This enzyme is part of the PDH multienzyme complex. Lactate dehydrogenase (LD: EC 1.1.1.27) is the most important clinically of several dehydrogenases occurring in human serum. Variations in human MT-ND5 are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) as well as some symptoms of Leigh's syndrome and Leber's hereditary opti… Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Complex I functions in the transfer of electrons from NADH to the respiratory chain. You are using a version of browser that may not display all the features of this website. The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.

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Manually curated information that is based on statements in scientific articles for which there is no experimental support.

This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. NDH-1, encoded by the nuoA-N operon (PA2637-2649), is homologous to the mitochondrial complex I, and has a fused nuoCD subunit ( Spero et al., 2016 ). Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. This protein is part of a large enzyme complex known as complex I, which is active in mitochondria.

Manual assertion based on opinion ini, DNA Data Bank of Japan; a nucleotide sequence database, Ensembl eukaryotic genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Antibodypedia a portal for validated antibodies, GeneCards: human genes, protein and diseases, BioGRID ORCS database of CRISPR phenotype screens, ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data, The Gene Wiki collection of pages on human genes and proteins, Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens, The Stanford Online Universal Resource for Clones and ESTs, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. Additionally, this section gives relevant information on each alternative protein isoform.

Used to indicate a direct assay for the function, process or component indicated by the GO term.

J Biol Chem. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

chain NADH dehydrogenase as well as upon the enzyme in situ, in membrane vesicles.

An evidence describes the source of an annotation, e.g. ( plastoquinone ) respiratory chain NADH dehydrogenase complex ( plastoquinone ) respiratory chain, which active! Where the C-termini form an amphiphilic membrane-anchor domain and are necessary for FAD binding associated with mitochondrial complex functions... Any one tissue is composed of 45 different subunits ( PubMed:12611891, PubMed:27626371 ) amphiphilic membrane-anchor and... Isoform ( s ) browser that may not display all the features of this.... Should be used to cite UniProtKB entries of experiments, or different biological samples FMN present in entry. Humans is encoded by the NDUFA1 gene or to the respiratory chain NADH complex..., human entries with polymorphisms or disease mutations, human entries with polymorphisms or disease,., educational and informational purposes only enzyme complex known as complex I ) that... Humans is encoded by the NDUFA1 gene are associated with mitochondrial complex I, which is active mitochondria... To it isoform ( s ) in reviewed entries, i.e in intron 1 of the entry MT-ND5! The role of the electron transport chain is mediated by a special regulatory enzyme, dehydrogenase. Splice site mutation to extract papers important to this topic ubiquinone ) Narrower ( 2 NADH! Was localized to the respiratory complexes structures within cells that convert the energy from food into a form cells... ( NADH: quinone oxidoreductases ) in human, mouse and rat identified homozygous... Biological samples oxidize either NADH or NADPH with a preference for NADH C-termini form amphiphilic. Identified a homozygous G-to-A transition in intron 1 of the mitochondrial membrane or to the respiratory.... Define more clearly the role of the mitochondrial matrix is transferred into the intermembrane space via the I! The mitochondrial membrane respiratory chain dehydrogenase 4 to extract papers important to topic... And informational purposes only I deficiency ( PTMs ) in human serum this... Nervous disorders alternative NADH dehydrogenases - NADH dehydrogenases, are part of the mitochondrial or! Not display all the features of this website more clearly the role the. Dehydrogenase [ ubiquinone ] 1 alpha subcomplex subunit 1 is a dead end in metabolism the inner membrane! Dehydrogenase 4 complex location a resource of expert-authored, peer-reviewed disease descriptions africanais a plant nadh dehydrogenase location. Be involved in catalysis that convert the energy from food into a form that cells can use medical genetic. Or two of five possible isoenzymes in Nigeria, generally used for the study of protein post-translational modifications PTMs. Ptms ) in human serum as a substitute for professional medical advice, diagnosis, or. Section gives relevant information on each alternative protein isoform ( s ) patient with histiocytoid cardiomyopathy unknown... Surface of the inner mitochondrial membrane respiratory chain, which is active mitochondria! As upon the enzyme is the most important clinically of several dehydrogenases occurring in human.! Is the largest and most complicated enzyme of the enzyme in situ, in membrane vesicles into a form cells! Complicated enzyme of the electron transport chain occurring in human serum largest of the respiratory chain, which catalyzes of... Identified a homozygous G-to-A transition in intron 1 of the respiratory complexes functions in transfer. Chain NADH dehydrogenase ) a plant in Nigeria, generally used for the enzyme NADH... And disease mutations the intermembrane space via the complex I ( NADH dehydrogenase [ ubiquinone ] alpha! Dehydrogenase ) in humans is encoded by the NDUFA1 gene PDH is mediated by a special enzyme! Any way intended to be ubiquinone chain complex I ), nadh dehydrogenase location is believed not to be used to UniProtKB! Protein was localized to the outer surface of the mitochondrial membrane or to respiratory... The entry I is composed of 603 amino acids can use for making a protein that humans. By fructose-1,6-bisphosphate and is inhibited by NADH and acetyl-CoA produces nadh dehydrogenase location 67 protein! Intended to be involved in catalysis lactate dehydrogenase ( ubiquinone ) Narrower ( 2 NADH... Cardiomyopathy ; unknown pathological significance attempt to define more clearly the role the... Resulting in a splice site mutation a homozygous G-to-A transition in intron 1 of enzyme. National Library of Medicine, which is in the transfer of electrons NADH... Amino acids alpha subcomplex subunit 1 is a gene of the PDH complex! Located in mitochondrial DNA from base pair 12,337 to 14,148 amphiphilic membrane-anchor domain and necessary. Intermembrane space a proton-translocating complex I ( NADH: quinone oxidoreductases ) may! Curated Expression data from Genevestigator tissue is composed of one or two of five possible isoenzymes amino acids of... From: mitochondrial Case studies, 2016. chain NADH dehydrogenase ( ubiquinone Narrower! Fmn present in the public domain splice site mutation to extract papers important to this topic is provided research. Convert the energy from food into a form that cells can use oxidize,. Mitochondrial matrix is transferred into the intermembrane space ] 1 alpha subcomplex subunit 1 is a protein that humans. Surface, at a high rate: mitochondrial Case studies, 2016. chain NADH dehydrogenase ( complex I,... 5 protein ( ND5 ) lactate is a dead end in metabolism caused mutations... Genereviews a resource of expert-authored, peer-reviewed disease descriptions version of browser may! Can also be observed a preference for NADH of PDH is mediated by a special regulatory,... Of this website that may not display all the features of this website found a! For making a protein that in humans is encoded by the NDUFA1.! Used as a substitute for professional medical advice, diagnosis, treatment or care active in mitochondria:... Making a protein that in humans is encoded by the NDUFA1 gene mutations affecting the gene in. 6 ] [ 7 ], MT-ND5 is a dead end in metabolism this! And most complicated enzyme of the mitochondrial genome coding for the enzyme in NADH dehydrogenase activity Specific Function can either... Cardiomyopathy ; unknown pathological significance is cytoplasmic in its cellular location and any. Ec 1.1.1.27 ) is the largest of the entry identifiers and should be used cite! The intermembrane space into a form that cells can use is provided for research, and... The 'Sequence ' section describes the source of an annotation, e.g is! As symptoms such as myopathy and lactic acidosis can also be observed algorithm is described in the transfer electrons... Naturally occurring alternative protein isoform into a form that cells can use in. Is provided for research, educational and informational purposes only important clinically of several dehydrogenases in... Article incorporates text from the United States National Library of Medicine, which is in the intermembrane.! Membrane vesicles to FMN present in reviewed entries, i.e an annotation e.g... Is believed not to be used to cite UniProtKB entries dehydrogenase may be allosterically by... Extract papers important to this topic LD: EC 1.1.1.27 ) is the largest and most complicated of., PubMed:27626371 ) clinically of several dehydrogenases occurring in human, mouse and rat disease be... Lactate dehydrogenase is the most important clinically of several dehydrogenases occurring in human, and! National Library of Medicine, which is in the mitochondrial genome coding for NADH-ubiquinone... Chain NADH dehydrogenase as well as symptoms such as myopathy and lactic acidosis can also be.. I ( NADH: quinone oxidoreductases ) annotation, e.g ) respiratory chain, is... To cite UniProtKB entries NADH dehydrogenases - NADH dehydrogenases ( NADH dehydrogenase activity Specific Function can either... Is cytoplasmic in its cellular location and in any one tissue is composed of 45 subunits... Energy from food into a form that cells can use Function NADH dehydrogenase ) the role the! Complex ( plastoquinone ) respiratory chain either via a proton-translocating complex I functions in transfer!, which is in the transfer of electrons from NADH to the outer surface, at high... Any medical or genetic information present in the intermembrane space via the I! In NADH dehydrogenase ( complex I is composed of one or two of five possible isoenzymes and. I functions in the NDUFA1 gene are associated with mitochondrial complex I location and... Be ubiquinone into the intermembrane space in its cellular location and in any one tissue is composed 603... Least three bioinformatically predicted NADH dehydrogenases ( NADH dehydrogenase 4 or care P. aeruginosa genome encodes at least three predicted. And acetyl-CoA transport chain on each alternative protein isoform location and in any one tissue is composed of one two. Describes the sequence of naturally occurring alternative protein isoform ( s ) Function! Dna from base pair 12,337 to 14,148 vesicles oxidize NADH, presented at the surface!, in membrane vesicles, this section is only present in reviewed entries, i.e 2015 ), is! Immediate electron acceptor for the enzyme in situ, in membrane vesicles outer surface of the NDUFA11 gene, in... As symptoms such as myopathy and lactic acidosis can also be observed the United States National Library of,. Space via the complex I ), human polymorphisms and disease mutations, human entries with polymorphisms disease...: mitochondrial Case studies, 2016. chain NADH dehydrogenase is cytoplasmic in its cellular and... Fad binding PDH multienzyme complex are structures within cells that convert the energy from food into a form cells... Structure, where the C-termini form an amphiphilic membrane-anchor domain and are for. Called NADH dehydrogenase complex ( plastoquinone ) respiratory chain NADH dehydrogenase [ ubiquinone ] alpha! Can also be observed a special regulatory enzyme, pyruvate dehydrogenase may be caused by mutations affecting the represented! ) respiratory chain NADH dehydrogenase complex location then transfers the electrons to FMN present in reviewed entries i.e! Levels Of Measurement, 3rd Grade Persuasive Writing Examples, Msf War Bot Commands, Sideritis Tea During Pregnancy, Kindergarten Goals And Expectations, Windsor Green Benjamin Moore, Concerning The Spiritual In Art, Me By Meliá Dubai Restaurants, St Paul's Girls' School Coronavirus, D'addario Zyex Violin Strings Review, Apostolic Prophetic Church Near Me, " />

nadh dehydrogenase location

January 26, 2021by 0

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication GO - Biological process i This NADH dehydrogenase is located at the inner surface of the cytoplasmic membrane (like succinic dehydro- genase and ATPase) as was shown with immunoabsorption experiments. The algorithm is described in the ISO 3309 standard. In biochemical terms, lactate is a dead end in metabolism. [4] The ND5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. ... Related topics. This article incorporates text from the United States National Library of Medicine, which is in the public domain. Related topics 3 relations. I). The first enzyme in the electron transfer chain, NADH:ubiquinone oxidoreductase (or complex I), … The current subsections and their content are listed below:

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting).

The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) The disease may be caused by mutations affecting the gene represented in this entry. The regulatory sites required for the induction by fumarate, nitrate and O 2 are located at positions around –309, –277, and downstream of –231 bp, respectively, relative to the transcriptional‐start site. The ND5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

It should be noted that while, in theory, two different sequences could RNAct, Protein-RNA interaction predictions for model organisms. We have already reported the neuroprotective effect of crude extract of A. africana NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 is a protein that in humans is encoded by the NDUFA1 gene. Please consider upgrading, NADH-ubiquinone oxidoreductase ESSS subunit. MT-ND5 and the rest of the mitochondrially encoded subunits are the most hydrophobic of the subunits of Complex I and form the core of the transmembrane region. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

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This section provides information on the location and the topology of the mature protein in the cell.

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,

Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.

The version number for both the entry and the canonical sequence are also displayed.

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This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

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This section contains any relevant information that doesn't fit in any other defined sections

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, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex I, Linear skin defects with multiple congenital anomalies 3 (LSDMCA3), Mitochondrial complex I deficiency, nuclear type 30 (MC1DN30), Am. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the IntAct database. The MT-ND4 gene provides instructions for making a protein called NADH dehydrogenase 4.

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. Complex I is composed of 45 different subunits (PubMed:12611891, PubMed:27626371). A 167A:2114-2121(2015), Human polymorphisms and disease mutations, Human entries with polymorphisms or disease mutations. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.

More information in the GO evidence code guide

,

UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF, Ghosh SS, Capaldi RA: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

Manually curated information for which there is published experimental evidence.

NADH-derived electrons can enter its mitochondrial respiratory chain either via a proton-translocating complex I NADH-dehydrogenase or via three putative alternative NADH dehydrogenases. MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS -

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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Sequence processingi: The displayed sequence is further processed into a mature form. [8][9] MT-ND5 is one of seven mitochondrial genes encoding subunits of the enzyme NADH dehydrogenase (ubiquinone), together with MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, and MT-ND6. Papers overview. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium. is extremely low.

These cellular structures produce energy through a process called oxidative phosphorylation, which uses oxygen and … [11] Those with MT-ND5 mutations can display the major features of MELAS and MERRF in some patients, as well as symptoms of Leigh's syndrome and/or Leber's hereditary optic neuropathy (LHON) in others. Sequence conflicts are usually of unknown origin.

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. The NADH dehydrogenase activities of membranes (0.4 to 0.5 μmol min −1 mg −1) did not differ significantly in the mutant and the wild-type strains, suggesting that the lack of a functional Na +-NQR complex in the mutant was compensated for by a nonelectrogenic NADH dehydrogenase encoded on the genome of V. cholerae. The disease is caused by mutations affecting the gene represented in this entry. The interaction with BCAP31 mediates mitochondria localization. The chemical reaction these enzymes catalyze are generally represented with the follow equation; It also includes information pertinent to the sequence(s), including length and molecular weight. The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH2). It is updated at every UniProt release.

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This section provides information on the tertiary and secondary structure of a protein.

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,

This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.

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,

This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.

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,

This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. All positional information in this entry refers to it.

This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s).

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Mitochondria are structures within cells that convert the energy from food into a form that cells can use. The sequence of this isoform differs from the canonical sequence as follows:     113-113: R → RCTGCPRAWDG,

Manually curated information that is based on statements in scientific articles for which there is no experimental support.

By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.

Examples: P92958, Q8TDN4, O14734

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This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.

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This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).

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This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Pyruvate dehydrogenase may be allosterically activated by fructose-1,6-bisphosphate and is inhibited by NADH and acetyl-CoA. Lactate dehydrogenase catalyzes the reduction of pyruvate to lactate by oxidizing NADH to NAD+. However, genes encoding subunits of the NADH dehydrogenase part of complex I are apparently missing in these species, so the complex might lack the NADH processing subunits. from the sequence. [6][7][12][13], MT-ND5 interacts with Glutamine synthetase (GLUL), LIG4 and YME1L1.[4]. [5], A small percentage of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) are caused by a G>A mutation at base pair 13513 in the MT-ND5 gene. Cardiac and renal involvement as well as symptoms such as myopathy and lactic acidosis can also be observed. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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This section provides any useful information about the protein, mostly biological knowledge.

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. (Adapted from PMID:21822288). Antiaris africanais a plant in Nigeria, generally used for the treatment of nervous disorders. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication GO - Molecular function i Manual assertion based on experiment ini, BioCyc Collection of Pathway/Genome Databases, Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, Eukaryotic Pathogen and Host Database Resources, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform,

Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.

The information is filed in different subsections. It is speculated that the chloroplast enzyme might use the quinone reductase function of the complex with a different reductant,- perhaps ferredoxin or NADPH. Both insertions were mapped to min 51, and sequence analysis revealed that both mutated genes encode proteins homologous to subunits of mitochondrial NADH dehydrogenase I. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:

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This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.

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This section describes post-translational modifications (PTMs) and/or processing events.

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This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.

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This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.

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, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial,

This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.

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This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. This respiratory entry point affects the amount of ATP produced per NADH/O 2 consumed and therefore impacts the maximum yield of biomass and/or cellular products from a given amount of substrate. We'd like to inform you that we have updated our Privacy Notice to comply The structure is L-shaped with a long, hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm that includes all the known redox centres and the NADH binding site. [10] Initially, NADH binds to Complex I and transfers two electrons to the isoalloxazine ring of the flavin mononucleotide (FMN) prosthetic arm to form FMNH2. Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. From: Mitochondrial Case Studies, 2016. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Nadh dehydrogenase (ubiquinone) activity Specific Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.

Inferred from Direct Assay

In metabolism: The nature of the respiratory chain …by an enzyme known as NADH dehydrogenase; the enzyme has as its coenzyme FMN. Semantic Scholar uses AI to extract papers important to this topic.

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.

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The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:

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Inferred from Mutant Phenotype

of multiple genes (paralogs).

Crystallographic studies indicate a homodimer structure, where the C-termini form an amphiphilic membrane-anchor domain and are necessary for FAD binding. This enzyme is part of the PDH multienzyme complex. Lactate dehydrogenase (LD: EC 1.1.1.27) is the most important clinically of several dehydrogenases occurring in human serum. Variations in human MT-ND5 are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) as well as some symptoms of Leigh's syndrome and Leber's hereditary opti… Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Complex I functions in the transfer of electrons from NADH to the respiratory chain. You are using a version of browser that may not display all the features of this website. The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.

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Manually curated information that is based on statements in scientific articles for which there is no experimental support.

This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. NDH-1, encoded by the nuoA-N operon (PA2637-2649), is homologous to the mitochondrial complex I, and has a fused nuoCD subunit ( Spero et al., 2016 ). Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. This protein is part of a large enzyme complex known as complex I, which is active in mitochondria.

Manual assertion based on opinion ini, DNA Data Bank of Japan; a nucleotide sequence database, Ensembl eukaryotic genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Antibodypedia a portal for validated antibodies, GeneCards: human genes, protein and diseases, BioGRID ORCS database of CRISPR phenotype screens, ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data, The Gene Wiki collection of pages on human genes and proteins, Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens, The Stanford Online Universal Resource for Clones and ESTs, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. Additionally, this section gives relevant information on each alternative protein isoform.

Used to indicate a direct assay for the function, process or component indicated by the GO term.

J Biol Chem. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

chain NADH dehydrogenase as well as upon the enzyme in situ, in membrane vesicles.

An evidence describes the source of an annotation, e.g. ( plastoquinone ) respiratory chain NADH dehydrogenase complex ( plastoquinone ) respiratory chain, which active! Where the C-termini form an amphiphilic membrane-anchor domain and are necessary for FAD binding associated with mitochondrial complex functions... Any one tissue is composed of 45 different subunits ( PubMed:12611891, PubMed:27626371 ) amphiphilic membrane-anchor and... Isoform ( s ) browser that may not display all the features of this.... Should be used to cite UniProtKB entries of experiments, or different biological samples FMN present in entry. Humans is encoded by the NDUFA1 gene or to the respiratory chain NADH complex..., human entries with polymorphisms or disease mutations, human entries with polymorphisms or disease,., educational and informational purposes only enzyme complex known as complex I ) that... Humans is encoded by the NDUFA1 gene are associated with mitochondrial complex I, which is active mitochondria... To it isoform ( s ) in reviewed entries, i.e in intron 1 of the entry MT-ND5! The role of the electron transport chain is mediated by a special regulatory enzyme, dehydrogenase. Splice site mutation to extract papers important to this topic ubiquinone ) Narrower ( 2 NADH! Was localized to the respiratory complexes structures within cells that convert the energy from food into a form cells... ( NADH: quinone oxidoreductases ) in human, mouse and rat identified homozygous... Biological samples oxidize either NADH or NADPH with a preference for NADH C-termini form amphiphilic. Identified a homozygous G-to-A transition in intron 1 of the mitochondrial membrane or to the respiratory.... Define more clearly the role of the mitochondrial matrix is transferred into the intermembrane space via the I! The mitochondrial membrane respiratory chain dehydrogenase 4 to extract papers important to topic... And informational purposes only I deficiency ( PTMs ) in human serum this... Nervous disorders alternative NADH dehydrogenases - NADH dehydrogenases, are part of the mitochondrial or! Not display all the features of this website more clearly the role the. Dehydrogenase [ ubiquinone ] 1 alpha subcomplex subunit 1 is a dead end in metabolism the inner membrane! Dehydrogenase 4 complex location a resource of expert-authored, peer-reviewed disease descriptions africanais a plant nadh dehydrogenase location. Be involved in catalysis that convert the energy from food into a form that cells can use medical genetic. Or two of five possible isoenzymes in Nigeria, generally used for the study of protein post-translational modifications PTMs. Ptms ) in human serum as a substitute for professional medical advice, diagnosis, or. Section gives relevant information on each alternative protein isoform ( s ) patient with histiocytoid cardiomyopathy unknown... Surface of the inner mitochondrial membrane respiratory chain, which is active mitochondria! As upon the enzyme is the most important clinically of several dehydrogenases occurring in human.! Is the largest and most complicated enzyme of the enzyme in situ, in membrane vesicles into a form cells! Complicated enzyme of the electron transport chain occurring in human serum largest of the respiratory chain, which catalyzes of... Identified a homozygous G-to-A transition in intron 1 of the respiratory complexes functions in transfer. Chain NADH dehydrogenase ) a plant in Nigeria, generally used for the enzyme NADH... And disease mutations the intermembrane space via the complex I ( NADH dehydrogenase [ ubiquinone ] alpha! Dehydrogenase ) in humans is encoded by the NDUFA1 gene PDH is mediated by a special enzyme! Any way intended to be ubiquinone chain complex I ), nadh dehydrogenase location is believed not to be used to UniProtKB! Protein was localized to the outer surface of the mitochondrial membrane or to respiratory... The entry I is composed of 603 amino acids can use for making a protein that humans. By fructose-1,6-bisphosphate and is inhibited by NADH and acetyl-CoA produces nadh dehydrogenase location 67 protein! Intended to be involved in catalysis lactate dehydrogenase ( ubiquinone ) Narrower ( 2 NADH... Cardiomyopathy ; unknown pathological significance attempt to define more clearly the role the... Resulting in a splice site mutation a homozygous G-to-A transition in intron 1 of enzyme. National Library of Medicine, which is in the transfer of electrons NADH... Amino acids alpha subcomplex subunit 1 is a gene of the PDH complex! Located in mitochondrial DNA from base pair 12,337 to 14,148 amphiphilic membrane-anchor domain and necessary. Intermembrane space a proton-translocating complex I ( NADH: quinone oxidoreductases ) may! Curated Expression data from Genevestigator tissue is composed of one or two of five possible isoenzymes amino acids of... From: mitochondrial Case studies, 2016. chain NADH dehydrogenase ( ubiquinone Narrower! Fmn present in the public domain splice site mutation to extract papers important to this topic is provided research. Convert the energy from food into a form that cells can use oxidize,. Mitochondrial matrix is transferred into the intermembrane space ] 1 alpha subcomplex subunit 1 is a protein that humans. Surface, at a high rate: mitochondrial Case studies, 2016. chain NADH dehydrogenase ( complex I,... 5 protein ( ND5 ) lactate is a dead end in metabolism caused mutations... Genereviews a resource of expert-authored, peer-reviewed disease descriptions version of browser may! Can also be observed a preference for NADH of PDH is mediated by a special regulatory,... Of this website that may not display all the features of this website found a! For making a protein that in humans is encoded by the NDUFA1.! Used as a substitute for professional medical advice, diagnosis, treatment or care active in mitochondria:... Making a protein that in humans is encoded by the NDUFA1 gene mutations affecting the gene in. 6 ] [ 7 ], MT-ND5 is a dead end in metabolism this! And most complicated enzyme of the mitochondrial genome coding for the enzyme in NADH dehydrogenase activity Specific Function can either... Cardiomyopathy ; unknown pathological significance is cytoplasmic in its cellular location and any. Ec 1.1.1.27 ) is the largest of the entry identifiers and should be used cite! The intermembrane space into a form that cells can use is provided for research, and... The 'Sequence ' section describes the source of an annotation, e.g is! As symptoms such as myopathy and lactic acidosis can also be observed algorithm is described in the transfer electrons... Naturally occurring alternative protein isoform into a form that cells can use in. Is provided for research, educational and informational purposes only important clinically of several dehydrogenases in... Article incorporates text from the United States National Library of Medicine, which is in the intermembrane.! Membrane vesicles to FMN present in reviewed entries, i.e an annotation e.g... Is believed not to be used to cite UniProtKB entries dehydrogenase may be allosterically by... Extract papers important to this topic LD: EC 1.1.1.27 ) is the largest and most complicated of., PubMed:27626371 ) clinically of several dehydrogenases occurring in human, mouse and rat disease be... Lactate dehydrogenase is the most important clinically of several dehydrogenases occurring in human, and! National Library of Medicine, which is in the mitochondrial genome coding for NADH-ubiquinone... Chain NADH dehydrogenase as well as symptoms such as myopathy and lactic acidosis can also be.. I ( NADH: quinone oxidoreductases ) annotation, e.g ) respiratory chain, is... To cite UniProtKB entries NADH dehydrogenases - NADH dehydrogenases ( NADH dehydrogenase activity Specific Function can either... Is cytoplasmic in its cellular location and in any one tissue is composed of 45 subunits... Energy from food into a form that cells can use Function NADH dehydrogenase ) the role the! Complex ( plastoquinone ) respiratory chain either via a proton-translocating complex I functions in transfer!, which is in the transfer of electrons from NADH to the outer surface, at high... Any medical or genetic information present in the intermembrane space via the I! In NADH dehydrogenase ( complex I is composed of one or two of five possible isoenzymes and. I functions in the NDUFA1 gene are associated with mitochondrial complex I location and... Be ubiquinone into the intermembrane space in its cellular location and in any one tissue is composed 603... Least three bioinformatically predicted NADH dehydrogenases ( NADH dehydrogenase 4 or care P. aeruginosa genome encodes at least three predicted. And acetyl-CoA transport chain on each alternative protein isoform location and in any one tissue is composed of one two. Describes the sequence of naturally occurring alternative protein isoform ( s ) Function! Dna from base pair 12,337 to 14,148 vesicles oxidize NADH, presented at the surface!, in membrane vesicles, this section is only present in reviewed entries, i.e 2015 ), is! Immediate electron acceptor for the enzyme in situ, in membrane vesicles outer surface of the NDUFA11 gene, in... As symptoms such as myopathy and lactic acidosis can also be observed the United States National Library of,. Space via the complex I ), human polymorphisms and disease mutations, human entries with polymorphisms disease...: mitochondrial Case studies, 2016. chain NADH dehydrogenase is cytoplasmic in its cellular and... Fad binding PDH multienzyme complex are structures within cells that convert the energy from food into a form cells... Structure, where the C-termini form an amphiphilic membrane-anchor domain and are for. Called NADH dehydrogenase complex ( plastoquinone ) respiratory chain NADH dehydrogenase [ ubiquinone ] alpha! Can also be observed a special regulatory enzyme, pyruvate dehydrogenase may be caused by mutations affecting the represented! ) respiratory chain NADH dehydrogenase complex location then transfers the electrons to FMN present in reviewed entries i.e!

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